IntroductionAlthough breast cancer is the most common malignancy in women, with approximately 230,000 cases diagnosed yearly in the United States,1 most patients are diagnosed with early-stage breast cancer (stage I/II). These patients have a high rate of cure with surgery and adjuvant therapies, such as radiation, chemotherapy, hormonal therapy, and biologic therapy.2 Detection of metastatic disease allows patients who cannot be cured to proceed to systemic therapy and avoid morbidity of loco-regional surgical therapy. Thus, accurate staging of breast cancer provides prognostic information and guides treatment decisions.3,4
Clinical staging for breast cancer is based on history, physical examination, laboratory work, and breast imaging. Advanced radiology studies such as positron emission tomography (PET), computed tomography (CT), integrated PET with CT (PET-CT), or bone scan may be used to determine if disease is present outside of the breast and axilla (metastatic sites). National guidelines do not recommend routine staging scans for asymptomatic patients with clinical stage I or II breast cancer.4,5 This recommendation is based on data from several studies demonstrating that asymptomatic but radiologically evident metastases are rare in this group of patients, with a median prevalence of 0.2% and 1.2% for stage I and stage II disease, respectively.6-15 In addition, staging scans are expensive, CT scans result in additional radiation exposure, and false-positive scans are common.9,11,16-18 False-positive scans are of special concern in patients with cancer because they may cause significant emotional distress and treatment delays, and can harm patients by the invasive procedures necessary to investigate abnormalities.
The Choosing Wisely campaign is a national physician and patient-centered initiative from the American Board of Internal Medicine meant to reduce healthcare practices that offer limited benefit to patients. The American Society of Clinical Oncology (ASCO) has contributed several recommendations about cancer care to the Choosing Wisely campaign.19 In 2013 ASCO officially recommended to “not perform PET, CT, and radionuclide bone scans in the staging of early breast cancer at low risk for metastasis” (ductal carcinoma in situ, clinical stage I or II) because the incidence of asymptomatic, radiologically evident metastatic cancer is low.19 This recommendation is consistent with other national guidelines.4 Clinical practice at the University of Vermont Cancer Center (UVMCC) had been to obtain routine staging scans for all patients with breast cancer who had clinical or pathologic nodal involvement, because patients with lymph node–positive disease have a higher likelihood of metastatic disease and, consequently, a very different prognosis and treatment options. We conducted the current study to evaluate the effect of changing current clinical practice to be consistent with ASCO recommendations. We examined the effect on identification of asymptomatic but radiologically apparent metastatic disease, clinical management, and cost.
Materials and MethodsThis study was conducted at the UVMCC, located at the 450-bed tertiary care University of Vermont Medical Center in Burlington. The study was approved by the Institutional Review Board and the Protocol Review and Monitoring Committee of the UVMCC.
Patients: New cases of breast cancer diagnosed and treated at UVMCC between October 1, 2011, and September 30, 2013, were identified through the Vermont Cancer Registry. Patients who had undergone radionuclide bone scan, PET-CT, CT chest, CT abdomen, and CT pelvis during this time were identified from billing databases by Current Procedural Terminology codes. Patient charts were abstracted if scans were associated with an International Classification of Diseases-9 code for breast cancer. Patients were excluded from this cohort if they had undergone imaging during the study period but were diagnosed before October 1, 2011.
Data Sources: We obtained data from several sources: administrative billing, the Vermont Cancer Registry, and medical record abstractions. Medical records of imaged patients were reviewed by a physician to obtain the following variables: age, tumor/nodes/metastasis (TNM) clinical stage at presentation (American Joint Committee on Cancer, 7th edition), symp-toms potentially attributable to cancer, radiology scans ordered with results, final pathologic stage, tumor characteristics, and breast cancer treatment changes secondary to staging imaging. Clinical stage was documented by the treating physician and confirmed by chart review.
CT scans were obtained with intravenous contrast on multi-detector-row scanners with a reconstructed slice thickness of 3 mm. PET-CT scans were obtained with F18-fluorodexoyglucose and 3D time-of-flight PET imaging from skull vertex to feet with low-dose CT attenuation correction. Bone scans used Tc-99m with standard whole body bone images. Scan results were obtained by reviewing radiology reports signed by an attending radiologist. The staging scan was defined as the initial radio-graphic assessment obtained by each patient (PET-CT or bone scan with CT chest/abdomen ± pelvis) to assess a new diagnosis of breast cancer.
Definitions of “Indicated” and “Nonindicated” ScansStaging scans were categorized as “indicated” or “nonindicated” (Figure 1). The definitions for indicated and nonindicated scans were based on clinical stage in accordance with ASCO Choosing Wisely recommendations.19 Thus, scans were considered “indicat-ed” if patients had any of the following: clinical stage III or IV breast cancer, clinical stage 0/I/II with symptoms concerning for metastatic spread (bone pain, headache, abdominal pain, neuro-logic symptoms), abnormal serologic tests (liver function studies, complete blood count [CBC]), or findings suggestive of metastasis on routine preoperative studies. Scans in clinical stage 0/I/II pa-tients were considered “indicated” if final pathology revealed stage III disease, thus prompting metastatic work-up. Scans were con-sidered “nonindicated” if none of the above factors was present.
OutcomesStaging scan results were categorized (based on findings outside of the breast and axilla) into 4 groups:
1. Normal/benign: defined as scan with no abnormalities or minor abnormalities that did not require further investigation for cancer care.
2. Positive for radiologic evidence of metastasis: defined as imaging with features suggestive of malignancy outside of the breast and axillae (upstaging to metastatic disease) that was confirmed on biopsy and/or by further imaging (PET-CT, MRI, and CT scan).
3. Positive for second primary cancer: defined as biopsy revealing cancer of nonbreast origin originally detected by a staging scan for breast cancer.
4. False-positive: defined as staging imaging for which further investigation was recommended by radiology, and that further investigation was either unremarkable or not obtained at the discretion of the treating oncologist with no evidence of metastatic disease in the area of concern after at least 1 year of clinical follow-up.
Changes in patient management resulting from staging imaging were identified by physician chart review. Changes in management included deferral of breast surgery because of discovery of metastasis, breast chemotherapy regimen change, and change in radiation therapy sites.
Cost EstimatesCosts of staging imaging and follow-up investigations of abnormal staging scans were determined by the cost-to-charge ratio method.20 Charges for procedures and imaging studies were obtained from The University of Vermont Medical Center patient financial office. Charges were then corrected to costs by the 2013 institutional cost-to-charge ratio (0.514) as reported by the Centers for Medicare & Medicaid Services (CMS).21 Additional physician visits or physician referrals were not incorporated into cost estimates.
Statistical AnalysisDemographic data are presented as totals and means, with rang-es and standard deviations displayed where appropriate. Patient demographic proportions between the registry population and the cohort with imaging were compared using Χ2 tests and al-pha (α) = .05. We compared scan outcomes between indicated and nonindicated groups using a 2x2 contingency table with the Fisher exact test and two-tailed significance testing with α = .05. Analyses were performed in R (version 2.7.2, R Development Core Team).
During the study period, 683 patients received care at UVMCC for breast cancer (Figure 1). The mean patient age was 59.9 years (range, 26-92 years). Patient characteristics are listed in Table 1. Women with stage I or stage II disease represented 71.0% (485) of the cohort. During the study period, 95 (13.9%) newly diagnosed patients underwent staging imaging with either PET-CT or bone scan with CT chest/abdomen ± pelvis. Sixty-six (69.5%) of the staging examinations were performed for women with clinical stage I or II disease (Figure 2). Patients who had staging imaging were noted to have more aggressive tumor characteristics compared with the registry population (Table 1). Staged patients had significantly higher tumor grade (P = .01) and were more likely to be HER2+ (P = .001). Patients with imaging were also more likely to undergo mastectomy (P <.001) and were more likely to receive neoadjuvant chemotherapy (P <.001).
Indicated Versus Nonindicated Staging Imaging
The study found that 43% (41/95) of all staging scans were determined to be indicated. These women had symptoms concerning for metastatic spread (bone pain, headache, abdominal pain, neurologic symptoms), abnormal serologic tests (liver function studies, CBC), or findings suggestive of metastases on routine preoperative studies. In this group, 70% (29/41) of scans were performed for clinical stage III or greater disease.
Indicated scans resulted in upstaging in 21.9 % (9/41) of patients and clinical management changes in 21.9% (9/41). Indicated scans detected second primary cancer in 2% (1/41). The false-positive rate for women who had indicated scans was 19.5% (8/41). Of those false-positives, 62.5% (5/8) underwent further imaging and/or biopsy and 37.5% (3/8) had unremarkable clinical follow-up at a mean of 2.1 years (Figure 3A). Evaluating findings in only stage I/II patients with indicated scans (Figure 3B) revealed a false-positive rate of 25% (3/12) and upstaging in 8% (1/12). No patients in this group were found to have second primary cancers.
During the study period, 56.8% (54/95) of staging scans were determined to be nonindicated (Figure 3C). No patient in this group was upstaged; however, 2 patients were found to have second primary cancers and clinical management was changed in 1 patient. The false-positive rate for this group was 37% (20/54): 8 (40%) patients had unremarkable further imaging and/or biopsy, while 12 (60%) were followed clinically for mean of 2.09 years.
Comparative Utility of Breast Cancer Staging StrategiesIndicated scans (9/41; 21.9%) had statistically greater detection of metastases than did nonindicated scans (0/54; P <.001). Indicated scans were also statistically more likely than nonindicated scans (21.9% vs 1.85%; P <.01) to result in changes in clinical management. The false-positive rates of nonindicated scans and indicated scans were not significantly different (37.0% vs 19.5%; P =.07).
Costs of StagingThe total cost of nonindicated staging was $308,932.98 over the study period, or $5720.98 per patient (Table 2). This total included costs for staging imaging, follow-up scans, and diagnostic interventions. The cost of nonindicated staging imaging during the study window was $256,236. The 9 patients with abnormal, nonindicated staging who underwent further evaluation at the discretion of the treating oncologists received 27 additional imaging studies and 2 invasive diagnostic procedures. The cost of these investigations was $43,696 over an average of 2.13 years of poststaging follow-up.
Incidence of Asymptomatic Metastasis for Clinical Stage 0-II Disease at UVMOnly 2 of 623 newly diagnosed clinical stage 0/II patients had asymptomatic, radiologically evident metastases at the time of presentation. One patient had clinical stage 0 (grade III, ER+/ PR-/HER2+) and the other had clinical stage IIA (grade II, ER-/ PR-/HER2+, cT2N0) disease. Thus, the incidence of metastasis in all patients with early-stage breast cancer (clinical stage 0/II) was 0.3% (2/623).
DiscussionTo our knowledge, the current study represents the most recent cohort of US patients evaluated for the utility of staging for early breast cancer since Lee et al in 198110 and demonstrates that using current, more sophisticated imaging for staging does not enhance management of early-stage breast cancer. In our cohort, we had a very low rate of identification of metastatic disease in early-stage breast cancer. Our overall rate of identification of metastatic disease in clinical stage I/II breast cancer was 0.2% (1/485 women) with 0% (0/372) for stage I and 0.8% (1/113) for stage II. This is on the low end of published series, which have identified rates of 0.2% for stage I and 1.2% for stage II disease.6-15
Most women who had staging imaging in our cohort had risk factors for identification of asymptomatic metastases, such as lymph node involvement and aggressive tumor characteristics (grade III and HER2+). In our study, staging for all patients with lymph node–positive breast cancer did not upstage any patient and rarely resulted in clinical management changes. Thus, our analysis confirms that following ASCO recommendations promotes high-value breast cancer care and effectively identifies patients at increased risk of metastasis. As a result of this analysis, we have changed our practice to follow ASCO recommendations.
Indicated staging scans were associated with significantly greater detection of metastases (22%) and clinical management changes (22%), despite a high false-positive rate (19.5%). Non-indicated staging scans cost at least $5700 per patient and are associated with an even higher false-positive rate (37%). Use of the ASCO recommendations for imaging as outlined above could have avoided 54 staging scans. Our findings suggest that adoption of ASCO-recommended breast cancer staging practices may decrease imaging costs and reduce false-positive findings, especially in patients with lymph node involvement.
The low likelihood of radiologic upstaging that we observed in patients with early-stage breast cancer is supported by other studies (Table 3). Earlier studies were performed using liver ultrasound, chest x-ray, and bone scan, and identified metastatic disease in patients with asymptomatic stage I/II breast cancer in 1.4% to 5.6% of cases.10,12,13,15 More recent studies used CT chest and abdomen scans for staging identified asymptomatic disease in fewer (0%-1.9%) patients with stage I/II breast cancer.22-24 In these 3 studies, asymptomatic, radiologically evident metastases were observed in 0% to 0.2% of patients with stage I disease and in 0% to 1.9% of patients with stage II disease after CT chest/abdomen imaging. In a Canadian cohort published in 2014, most of those evaluations did not use CT-based imaging.23
Our study did not assess the emotional impact of nonindicated imaging, but additional testing provokes anxiety, especially when indeterminate or abnormal scans require further interventions.25,26 The false-positive rate of 37% that we observed is greater than that reported by Kim et al (13.4%-14.4%) and by Tanaka et al (7.7%-9.5%), but similar to the 25% false-positivity reported for a CT-based staging approach in the United Kingdom and to the 21.9%-35.1% of stage I/II patients that had further confirmatory imaging in Canada.22-24,27 The Choosing Wisely Campaign accurately describes the populations that should and should not be further staged; and patients with newly diagnosed stage I/ II breast cancer should be spared the emotional, physical, and financial burdens of routine staging imaging.
LimitationsOur study has limitations. Our cohort is smaller than other non-US cohorts, even though our findings are in accord with those studies.22,24 Second, our method of cost estimation may have wrongly estimated costs for breast cancer staging, since patient level charges are expected to vary as a result of negotiations by insurance providers and we did not include reimbursement for CMS part B or equivalent. Although claim reimbursement approaches provide cost estimates that more closely represent revenue, such approaches are labor-intensive, payments may not reflect the resources required to provide the service, and in-surer-specific prices have been shown to correlate well with the charge-to-cost ratio.28,29 Furthermore, our approach facilitated incorporation of downstream follow-up costs over several years, and our methodology is easily adaptable to cost structures at other institutions. Finally, the combination of bone scan and CT imaging used at our institution may complicate comparison to other studies, because the use of bone scan with CT for breast cancer staging does not appear to be common practice at other institutions.22-24
ConclusionUsing the staging criteria proposed by ASCO’s Choosing Wisely recommendations decreases the number of total imaging studies, false-positive scans, and imaging costs, without modifying the detection of asymptomatic metastases. Staging scans in patients with stage I/II breast cancer are unlikely to guide clinical decision making because of the rarity of asymptomatic metastases. In addition, the use of criteria-based imaging saves almost $6000 per patient. Two recent studies suggest that despite ASCO’s Choosing Wisely recommendations, women with early-stage breast cancer continue to receive unnecessary imaging evaluations, however,30,31 highlighting the importance of ongoing efforts to educate oncology providers.
Acknowledgments: We acknowledge the valuable support of Melissa Sands in preparation of this manuscript
Affiliations: Samuel A. Merrill, MD, PhD, is from the Department of Internal Medicine, University of Vermont. Pamela Stevens, RN, is from Jeffords Institute for Healthcare Effectiveness, University of Vermont Medical Center. Claire Verschraegen, MD, is from the Division of Hematology and Oncology, University of Vermont. Marie E. Wood, MD, is from the Division of Hematology and Oncology, University of Vermont.
Address correspondence to: Marie E. Wood, MD, Division of Hematology and Oncology, University of Vermont Cancer Center, Given E 217, 89 Beaumont Ave, Burlington, VT 05405. Phone: 802-847-8400; fax: 802-847-5618; email: Marie.Wood@ uvmhealth.org
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