Accreditation/Credit Designation

Physicians’ Education Resource®, LLC, is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

Physicians’ Education Resource®, LLC, designates this enduring material for a maximum of 1.0 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Acknowledgment of Support

This activity is supported by an educational grant from Sanofi Genzyme.

Community Practice Connections™: Harmonizing Clinical Practices: Strategies for Rapid Diagnosis and Acute Management of Acquired TTP

Release Date: September 15, 2021
Expiration Date: September 15, 2022

Activity Overview

Thrombotic thrombocytopenic purpura (TTP) is a rare, life-threatening thrombotic microangiopathy. In acquired TTP (aTTP), microthrombi form in small blood vessels throughout the body, causing hypoxia in organs including the brain, kidneys, and heart. The reported incidence of TTP is 2 to 6 cases per million per year, and the reported mortality is 10% to 20% with proper treatment. In recent years, a number of new therapeutic agents and regimens have been developed to properly manage aTTP requiring detailed guidance.

Acknowledgement of Commercial Support

This activity is supported by an educational grant from Sanofi Genzyme.

Instructions for This Activity and Receiving Credit

  1. Complete the activity (including pre- and post-activity assessments).
  2. Answer the evaluation questions.
  3. Request credit using the drop-down menu.

You may immediately download your certificate.

Target Audience

This activity is intended for hematologists and hematologist/oncologists who treat patients with aTTP. Fellows, nurses, nurse practitioners, physician assistants, and other health care professionals interested in the management of patients given a diagnosis of aTTP are also invited to participate.

Learning Objectives

Upon successful completion of this activity, you should be better prepared to:

  • Review diagnostic challenges that are specific to aTTP.
  • Apply disease-specific tests to diagnose aTTP based upon clinical manifestations.
  • Analyze clinical trial data of approved and investigational therapies for the treatment of aTTP.
  • Integrate clinical guideline recommendations into the management of aTTP.

Faculty, Staff, and Planners’ Disclosures

The staff of Physicians’ Education Resource®, LLC have no relevant financial relationships with ineligible entities.


Spero R. Cataland, MD
Spero R. Cataland, MD
Professor of Internal Medicine
Division of Hematology
Ohio State University Wexner Medical Center
Arthur G. James Cancer Hospital and Richard J. Solove Research Institute
Ohio State University
Columbus, OH

Disclosures: Grant Research Support: Sanofi Genzyme, Takeda Pharmaceutical, Alexion Pharmaceuticals; Consultant: Sanofi Genzyme, Takeda Pharmaceutical.

Marie Scully, MD
Marie Scully, MD
Professor of Haemostasis and Thrombosis
University of London
Clinical Lead, Thrombotic Microangiopathies
Consultant Haematologist
University College London Hospitals
National Health Service Foundation Trust
London, UK

Disclosures: Grant Research Support: Shire, Novartis Pharmaceuticals; Consultant: Takeda Pharmaceutical, Sanofi Genzyme, Octapharma USA, Novartis Pharmaceuticals; Shareholder: Takeda Pharmaceutical, Sanofi Genzyme, Octapharma USA, Novartis Pharmaceuticals.

PER® mitigated all COI for faculty, staff, and planners prior to the start of this activity by using a multistep process.

Off-Label Disclosure and Disclaimer

This activity may or may not discuss investigational, unapproved, or off-label use of drugs. Learners are advised to consult prescribing information for any products discussed. The information provided in this accredited activity is for continuing education purposes only and is not meant to substitute for the independent clinical judgment of a healthcare professional relative to diagnostic, treatment, or management options for a specific patient’s medical condition. The opinions expressed in the content are solely those of the individual faculty members and do not reflect those of PER® or any company that provided commercial support for this activity.

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